drugset / Trial / NCT01413750

Carboplatin and Paclitaxel With or Without Vorinostat in Treating Patients With Advanced Non-Small Cell Lung Cancer

NCT01413750

Phase 2 Terminated 23 enrolled National Cancer Institute (NCI)
RandomizedParallel-groupQuadruple-blindTreatment

Summary

Drugs used in chemotherapy, such as carboplatin and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Vorinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known whether giving carboplatin and paclitaxel together is more effective with or without vorinostat in treating non-small cell lung cancer.

Timeline

Start
2010-11-08
Primary completion
2013-04-14
Completion
2013-04-14

Drugs

EvaluationDrugModalityDoseRoute
Subject Vorinostat Small molecule Oral
Background Carboplatin Small molecule Intravenous
Background Paclitaxel Small molecule Intravenous