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drugset / Trial / NCT01418365

Metronidazole Drug Interaction Study With MMX® Mesalazine/Mesalamine

NCT01418365 ↗

Phase 1 Completed 30 enrolled Shire

RandomizedCrossoverOpen-labelTreatment

Summary

Drug interaction study evaluating the pharmacokinetic profiles of Metronidazole administered alone \& in combination with MMX® Mesalazine/mesalamine

Timeline

Start: 2011-08-22
Primary completion: 2011-10-05
Completion: 2011-10-05

Publications

Pierce D, Corcoran M, Martin P, Barrett K, Inglis S, Preston P, Thompson TN, Willsie SK. Effect of MMX(R) mesalamine coadministration on the pharmacokinetics of amoxicillin, ciprofloxacin XR, metronidazole, and sulfamethoxazole: results from four randomized clinical trials. Drug Des Devel Ther. 2014 May 14;8:529-43. doi: 10.2147/DDDT.S55373. eCollection 2014.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Mesalamine	Small molecule	4.8 g	—
Subject	Metronidazole	Small molecule	750 mg	Oral

Indications

No indication recorded.