TLR-9 Antagonism in Steroid Resistant Optic Neuritis

Summary

Although idiopathic steroid resistant optic neuritis is very uncommon, there is no established treatment protocol for such patients. Toll like receptors (TLRs) especially TLR-9 has been shown to play a role in the pathogenesis of optic neuritis. This small case series aims to determine whether immunomodulators directed specifically at TLR-9(i.e. TLR-9 antagonism)play any role in improving the visual function in such patients.

Timeline

Start

2006-07

Primary completion

2010-01

Completion

2010-05

Drugs

Indications