The Effects of Bethanechol on Glucose Homeostasis

Phase 1 Completed 50 enrolled Washington University School of Medicine National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · collab

Non-randomizedCrossoverSingle-blindBasic science

Summary

Xenin-25 and glucose-dependent insulinotropic polypeptide (GIP) are hormones produced in the intestine that are released into the blood immediately after ingestion of a meal. Together, these 2 hormones increase insulin release and reduce blood glucose levels. Xenin-25 works by increasing acetylcholine release in pancreatic islets. This study will determine if a Bethanechol, a drug that is similar to acetylcholine, also increases insulin release and reduces blood glucose levels after ingestion of a mixed meal.

Timeline

Start: 2011-08-15
Primary completion: 2014-07-07
Completion: 2014-07-07

Publications

Results Chowdhury S, Wang S, Dunai J, Kilpatrick R, Oestricker LZ, Wallendorf MJ, Patterson BW, Reeds DN, Wice BM. Hormonal Responses to Cholinergic Input Are Different in Humans with and without Type 2 Diabetes Mellitus. PLoS One. 2016 Jun 15;11(6):e0156852. doi: 10.1371/journal.pone.0156852. eCollection 2016.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Bethanechol	Small molecule	25 mg	Oral
Subject	Bethanechol	Small molecule	50 mg	Oral
Subject	Bethanechol	Small molecule	100 mg	Oral

The Effects of Bethanechol on Glucose Homeostasis

Summary

Timeline

Publications

Drugs

Indications