drugset / Trial / NCT01440478
The Effects of Urinary pH Changes on an Investigational Compound in Healthy Subjects
RandomizedCrossoverOpen-labelBasic science
Summary
This study is designed to explore the effect of increased and decreased urinary pH on the single pharmacokinetic (PK) dose of LY2140023 and its active metabolite LY404039. All participants will receive the three treatments in a randomized order.
Timeline
- Start
- 2011-09
- Primary completion
- 2011-10
- Completion
- 2011-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Ammonium Chloride | Small molecule | 1 g | Oral |
| Subject | LY2140023 | Unknown | 80 mg | — |
| Subject | sodium bicarbonate | Diagnostic / imaging agent | 4 g | — |
Indications
No indication recorded.