Evaluate the Absorption, Metabolism, And Excretion Of Orally Administered [14C] TR 701 In Healthy Adult Male Subjects

Phase 1 Completed 6 enrolled Merck & Co., Inc.

Non-randomizedSingle-groupOpen-labelTreatment

Summary

The purpose of this study is to describe the single dose pharmacokinetics of total radioactivity in plasma and whole blood following PO administration of \[14C\] TR-701 in healthy adult male subjects.

Timeline

Start: 2010-09-09
Primary completion: 2010-09-22
Completion: 2010-09-22

Publications

Results Ong V, Flanagan S, Fang E, Dreskin HJ, Locke JB, Bartizal K, Prokocimer P. Absorption, distribution, metabolism, and excretion of the novel antibacterial prodrug tedizolid phosphate. Drug Metab Dispos. 2014 Aug;42(8):1275-84. doi: 10.1124/dmd.113.056697. Epub 2014 May 29.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Tedizolid Phosphate	Small molecule	200 mg	Oral

Indications

No indication recorded.