drugset / Trial / NCT01443039
Phenotypical Approach of the Drug Metabolizing Hormones Activity Before and After Roux-en Y-Gastric Bypass
Phase 1
Completed
11 enrolled
Assistance Publique - Hôpitaux de Paris
Ministry of Health, France · collab
NaSingle-groupOpen-labelTreatment
Summary
The activity of drug-metabolizing enzymes and transporters evolutes after Roux-en-Y gastric Bypass. Primary aim : To study the intra individual evolution of phenotypical markers of different drug metabolizing enzymes and one transporter (CYP1A2, CYP2D6, CYP2C9, CYP2C19, CYP3A4 and P-gp), using a cocktail phenotypic approach, after Roux-en-Y gastric Bypass.
Timeline
- Start
- 2011-09
- Primary completion
- 2014-02
- Completion
- 2014-02
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Caffeine | Small molecule | 100 mg | Oral |
| Subject | DEXTROMETHORPHANE | Unknown | 30 mg | — |
| Subject | Digoxin | Other / unclassified | 0.5 mg | Oral |
| Subject | Losartan | Other / unclassified | 50 mg | — |
| Subject | Midazolam | Small molecule | 2 mg | Other |