drugset / Trial / NCT01462253

Clofarabine-cyclophosphamide as Salvage Therapy for Refractory and Relapsed Acute Lymphoblastic Leukemia (ALL) Adults

NCT01462253

Phase 2 Completed 35 enrolled GIMEMA Foundation
NaSingle-groupOpen-labelTreatment

Summary

This is a multicentric, prospective pilot trial testing a Clofarabine-Cyclophosphamide combination to treat refractory and first bone marrow relapse adult ALL, for the achievement of a complete remission (CR) and the concurrent evaluation of biological response in ALL cells (minimal residual disease, apoptosis and DNA cell damage, pharmacogenomics).

Timeline

Start
2012-10
Primary completion
2017-03-11
Completion
2017-03-11

Drugs

EvaluationDrugModalityDoseRoute
Subject Clofarabine Other / unclassified Intravenous
Subject Cyclophosphamide Other / unclassified Intravenous