A Study of Intra-Ophthalmic Artery Topotecan Infusion for the Treatment of Retinoblastoma

Summary

This study will test if giving topotecan directly into the blood vessel of the eye will improve the treatment of retinoblastoma. This method is referred to as "selective intra-ophthalmic artery chemotherapy" (SIOAC). The goals of this study are: * To find out if topotecan is an effective treatment for retinoblastoma when delivered directly to the ophthalmic artery (SIOAC delivery) * To find out what kind of effects (good and bad) can be expected when topotecan is given by SIOAC * To assess visual pathway function before and after the study therapy * To learn more about the pharmacology (how your body handles the drug) of topotecan when delivered directly to the ophthalmic artery

Timeline

Start

2011-10

Primary completion

2015-10

Completion

2015-10

Publications

• Abruzzo TA, Geller JI, Kimbrough DA, Michaels S, Correa ZM, Cornell K, Augsburger JJ. Adjunctive techniques for optimization of ocular hemodynamics in children undergoing ophthalmic artery infusion chemotherapy. J Neurointerv Surg. 2015 Oct;7(10):770-6. doi: 10.1136/neurintsurg-2014-011295. Epub 2014 Sep 1.

Drugs

Indications