drugset / Trial / NCT01471964

Study to Assess Safety and Tolerability of MLN8237, In Combination With Erlotinib to Treat Non-Small Cell Lung Cancer

NCT01471964

NaSingle-groupOpen-labelTreatment

Summary

This phase I/II trial studies the side effects and the best dose of MLN8237 when given together with erlotinib hydrochloride and to see how well it works in treating patients with recurrent locally advanced or metastatic non-small cell lung cancer (NSCLC). MLN8237 and erlotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Timeline

Start
2011-10-20
Primary completion
2017-02-07
Completion
2018-04-10

Drugs

EvaluationDrugModalityDoseRoute
Subject Alisertib Small molecule 30 mg
Subject Alisertib Small molecule 40 mg
Subject Alisertib Small molecule 50 mg
Subject Erlotinib Small molecule 100 mg
Subject Erlotinib Small molecule 150 mg