The Bolus Dose of Dexmedetomidine (ED50) That Avoids Hemodynamic Compromise in Children

Summary

Dexmedetomidine is a sedative drug that has many benefits when given to children under anesthesia, such as improved pain relief and reduced agitation following their surgery. It is usually given as an intravenous infusion over 10 minutes, to avoid the changes in heart rate and blood pressure that are occasionally seen when it is administered more quickly. However, this is often infeasible and usually inconvenient. The investigators aim to determine the dose of dexmedetomidine that can be given rapidly (over 5 seconds) without causing significant changes in heart rate and blood pressure. This will be the only study specific intervention.

Timeline

Start

2012-01

Primary completion

2013-09

Completion

2013-09

Drugs

Indications

No indication recorded.