drugset / Trial / NCT01505933

Airway Dimension Study in Children Undergoing MRI Sedated With Propofol and Dexmedetomidine

NCT01505933

Phase 2 Terminated 24 enrolled Milton S. Hershey Medical Center
RandomizedParallel-groupSingle-blindSupportive care

Summary

Sedation is required in infants and children to successfully complete MRI while maintaining respiratory and hemodynamic stability. Limited access to the patient may pose a safety risk during MRI examination. Therefore, appropriate drugs need to be selected, administered, and titrated to achieve these objectives. Propofol is commonly used for sedation in children in the MRI setting because of its predictability, rapid onset, and offset of action. Dexmedetomidine has sedative and analgesic properties without affecting cardiovascular and respiratory stability. The rationale of this research is to assess the effect of these drugs on the upper airway and validate their use in children with upper airway disorders.

Timeline

Start
2012-02
Primary completion
2017-12-01
Completion
2019-04-30

Drugs

EvaluationDrugModalityDoseRoute
Comparator Dexmedetomidine Other / unclassified 1 ug/kg
Comparator Dexmedetomidine Other / unclassified 3 ug/kg
Comparator Propofol Small molecule 100 ug/kg
Comparator Propofol Small molecule 240 ug/kg

Indications

No indication recorded.