drugset / Trial / NCT01505933
Airway Dimension Study in Children Undergoing MRI Sedated With Propofol and Dexmedetomidine
RandomizedParallel-groupSingle-blindSupportive care
Summary
Sedation is required in infants and children to successfully complete MRI while maintaining respiratory and hemodynamic stability. Limited access to the patient may pose a safety risk during MRI examination. Therefore, appropriate drugs need to be selected, administered, and titrated to achieve these objectives. Propofol is commonly used for sedation in children in the MRI setting because of its predictability, rapid onset, and offset of action. Dexmedetomidine has sedative and analgesic properties without affecting cardiovascular and respiratory stability. The rationale of this research is to assess the effect of these drugs on the upper airway and validate their use in children with upper airway disorders.
Timeline
- Start
- 2012-02
- Primary completion
- 2017-12-01
- Completion
- 2019-04-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Dexmedetomidine | Other / unclassified | 1 ug/kg | — |
| Comparator | Dexmedetomidine | Other / unclassified | 3 ug/kg | — |
| Comparator | Propofol | Small molecule | 100 ug/kg | — |
| Comparator | Propofol | Small molecule | 240 ug/kg | — |
Indications
No indication recorded.