Vitamin D3 Effects on Musculoskeletal Symptoms With Use of Aromatase Inhibitors

Phase 2 Completed 116 enrolled HealthPartners Institute University of Minnesota · collab University of Southern California · collab

RandomizedParallel-groupTriple-blindSupportive care

Summary

The Purpose of this study is to determine whether vitamin D3 supplements will decrease the muscle and bone pain that are reported by women who take Aromatase Inhibitors.

Timeline

Start: 2012-03
Primary completion: 2014-10
Completion: 2015-03

Publications

Results Shapiro AC, Adlis SA, Robien K, Kirstein MN, Liang S, Richter SA, Lerner RE. Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS). Breast Cancer Res Treat. 2016 Feb;155(3):501-12. doi: 10.1007/s10549-016-3710-6. Epub 2016 Feb 11.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Cholecalciferol	Other / unclassified	600 iu	—
Comparator	Cholecalciferol	Other / unclassified	4000 iu	—

Vitamin D3 Effects on Musculoskeletal Symptoms With Use of Aromatase Inhibitors

Summary

Timeline

Publications

Drugs

Indications