Vitamin D Metabolism in Chronic Kidney Disease Patients

Summary

To determine whether or not chronic kidney disease (CKD), stages III-V and ESRD , is associated with altered vitamin D metabolism related to fibroblast growth factor-23 (FGF-23) stimulation of Cyp24 and whether they have resistance to elevations of 25 Hydroxyvitamin D (25(OH)D3) after cholecalciferol supplementation. To determine if such resistance is related to enhanced catabolism of (25(OH)related to elevated levels of FGF-23.

Timeline

Start

2010-11

Primary completion

2012-12

Completion

2012-12

Publications

• Alshayeb H, Showkat A, Wall BM, Gyamlani GG, David V, Quarles LD. Activation of FGF-23 mediated vitamin D degradative pathways by cholecalciferol. J Clin Endocrinol Metab. 2014 Oct;99(10):E1830-7. doi: 10.1210/jc.2014-1308. Epub 2014 Jun 24.

Drugs

Indications