drugset / Trial / NCT01542255
Metronomic Therapy in Patients With Metastatic Melanoma
NaSingle-groupOpen-labelTreatment
Summary
SUMMARY: Metronomic Therapy in Patients with Metastatic Melanoma: A Phase II Study of Low Dose Vinblastine, Cyclophosphamide, and Dacarbazine. Patients with measurable metastatic melanoma are eligible. All patients will be treated as outlined below with combined vinblastine, cyclophosphamide, and dacarbazine. Patients will be treated continuously, until evidence of progression of disease, or for up to two cycles following disappearance of all disease. A cycle will be defined as three weeks of continuous therapy with a one week rest.
Timeline
- Start
- 2010-06
- Primary completion
- 2013-01
- Completion
- 2013-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cyclophosphamide | Other / unclassified | 60 mg/m2 | Oral |
| Subject | Dacarbazine | Small molecule | 15 mg/m2 | Intravenous |
| Subject | Vinblastine | Small molecule | 1 mg/m2 | Intravenous |