drugset / Trial / NCT01542255

Metronomic Therapy in Patients With Metastatic Melanoma

NCT01542255

Phase 2 Terminated 7 enrolled Dartmouth-Hitchcock Medical Center
NaSingle-groupOpen-labelTreatment

Summary

SUMMARY: Metronomic Therapy in Patients with Metastatic Melanoma: A Phase II Study of Low Dose Vinblastine, Cyclophosphamide, and Dacarbazine. Patients with measurable metastatic melanoma are eligible. All patients will be treated as outlined below with combined vinblastine, cyclophosphamide, and dacarbazine. Patients will be treated continuously, until evidence of progression of disease, or for up to two cycles following disappearance of all disease. A cycle will be defined as three weeks of continuous therapy with a one week rest.

Timeline

Start
2010-06
Primary completion
2013-01
Completion
2013-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Cyclophosphamide Other / unclassified 60 mg/m2 Oral
Subject Dacarbazine Small molecule 15 mg/m2 Intravenous
Subject Vinblastine Small molecule 1 mg/m2 Intravenous

Indications