Effect of Dentifrice Usage Regime on Delivery and Efficacy of Fluoride

Summary

This study will evaluate and compare the effect of the amount of toothpaste used and brushing time on enamel strengthening (percent of surface microhardness recovery, % SMHR) and enamel fluoride uptake (EFU).

Timeline

Start

2009-01-01

Primary completion

2009-06-01

Completion

2009-06-01

Outcome

Met primary endpoint

registry p = 0.0008; Least square (LS) mean difference 6.95 (95% CI 2.91 to 10.98) NCT01563172 ↗

Publications

• Results https://clinicaltrials.gov/ct2/show/results/NCT01563172?term=T3158587&rank=1
• Creeth JE, Kelly SA, Gonzalez-Cabezas C, Karwal R, Martinez-Mier EA, Lynch RJM, Bosma ML, Zero DT. Effect of toothbrushing duration and dentifrice quantity on enamel remineralisation: An in situ randomized clinical trial. J Dent. 2016 Dec;55:61-67. doi: 10.1016/j.jdent.2016.10.003. Epub 2016 Oct 4.

Drugs

Indications