drugset / Trial / NCT01566357
Impact of Milk on Erosion/Abrasion of Enamel and Dentin - an in Situ Study
RandomizedCrossoverSingle-blind
Summary
This in situ study aims to investigate * the protective potential of milk and fluoridated milk on erosive wear of enamel * the protective potential of milk and fluoridated milk on erosive wear of dentin * to compare to protective potential of milk and fluoridated milk with products containing casein phosphopeptide-amorphous calcium phosphate * to compare the protective potential of milk and fluoridated milk with a fluoridated toothpaste or stannous-chloride containing fluoride solution (SnCl2/AmF/NaF)
Timeline
- Start
- 2012-01
- Primary completion
- 2013-05
- Completion
- 2013-07
Publications
- Background Wiegand A, Muller I, Schnapp JD, Werner C, Attin T. Impact of fluoride, milk and water rinsing on surface rehardening of acid softened enamel. An in situ study. Am J Dent. 2008 Apr;21(2):113-8.
- Background Hemingway CA, White AJ, Shellis RP, Addy M, Parker DM, Barbour ME. Enamel erosion in dietary acids: inhibition by food proteins in vitro. Caries Res. 2010;44(6):525-30. doi: 10.1159/000320984. Epub 2010 Oct 28.
- Background White AJ, Gracia LH, Barbour ME. Inhibition of dental erosion by casein and casein-derived proteins. Caries Res. 2011;45(1):13-20. doi: 10.1159/000322300. Epub 2010 Dec 11.
- Background Wiegand A, Hiestand B, Sener B, Magalhaes AC, Roos M, Attin T. Effect of TiF4, ZrF4, HfF4 and AmF on erosion and erosion/abrasion of enamel and dentin in situ. Arch Oral Biol. 2010 Mar;55(3):223-8. doi: 10.1016/j.archoralbio.2009.11.007. Epub 2010 Jan 18.
- Wiegand A, Attin T. Randomised in situ trial on the effect of milk and CPP-ACP on dental erosion. J Dent. 2014 Sep;42(9):1210-5. doi: 10.1016/j.jdent.2014.07.009. Epub 2014 Jul 17.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | CPP-ACP | Protein / enzyme biologic | — | — |
| Comparator | CPP-ACPF | Unknown | 900 ppm | — |
| Comparator | Elmex Erosion Protection | Other / unclassified | — | — |
Indications
No indication recorded.