drugset / Trial / NCT01568944
Role of Infected Blood Dendritic Cells in Heart Disease Risk
Completed
18 enrolled
Augusta University
National Institute of Dental and Craniofacial Research (NIDCR) · collab
RandomizedParallel-groupSingle-blindOther
Summary
The investigators hypothesize that blood dendritic cells harbor pathogens from the oral cavity in chronic periodontitis and disseminate these pathogens to atherosclerotic plaques.
Timeline
- Start
- 2012-03
- Primary completion
- 2014-09
- Completion
- 2014-09
Publications
- Background Zeituni AE, McCaig W, Scisci E, Thanassi DG, Cutler CW. The native 67-kilodalton minor fimbria of Porphyromonas gingivalis is a novel glycoprotein with DC-SIGN-targeting motifs. J Bacteriol. 2010 Aug;192(16):4103-10. doi: 10.1128/JB.00275-10. Epub 2010 Jun 18.
- Background Zeituni AE, Carrion J, Cutler CW. Porphyromonas gingivalis-dendritic cell interactions: consequences for coronary artery disease. J Oral Microbiol. 2010 Dec 21;2. doi: 10.3402/jom.v2i0.5782.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Amoxicillin | Other / unclassified | 500 mg | Oral |
| Subject | Chlorhexidine | Small molecule | 0.12 % | Oral |
| Subject | Lansoprazole | Other / unclassified | 250 mg | Oral |
| Subject | Metronidazole | Small molecule | 250 mg | Oral |