drugset / Trial / NCT01570569
Development of Minidose Inje Cocktail Method for Simultaneous Evaluating Five Cytochrome P450 Isoforms in Human
RandomizedParallel-groupOpen-labelHealth-services research
Summary
The investigators objectives were developing mini dose five-drug cocktail regimen to evaluate potential drug-drug interactions associated with use of a cocktail of caffeine, losartan, omeprazole, dextromethorphan, and midazolam for simultaneous assessment of CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A activities.
Timeline
- Start
- 2011-01
- Primary completion
- 2011-03
- Completion
- 2011-03
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Caffeine | Small molecule | 2 mg | Oral |
| Comparator | Dextromethorphan | Unknown | 2 mg | Oral |
| Comparator | Losartan | Other / unclassified | 2 mg | Oral |
| Comparator | Midazolam | Small molecule | 100 ug | Oral |
| Comparator | Omeprazole | Other / unclassified | 200 ug | Oral |
Indications
No indication recorded.