drugset / Trial / NCT01587222

Midodrine, Octreotide and Albumin: Impact on Renal Function of Patients With Liver Cirrhosis and Renal Failure

NCT01587222

Phase 2 Withdrawn Anna Cruceta
NaSingle-groupOpen-labelTreatment

Summary

The aim of this study is to evaluate the treatment with midodrine, octreotide and albumin during 12 weeks in patients with hepatorenal syndrome. Fifteen patients will be enrolled and followed during 16 weeks. The effects on renal function will be evaluated 12 and 16 weeks after the beginning of the treatment by isotopic evidence and biochemist determinations. Also it will be evaluated arterial pressure and determination of vasoactive hormones (plasma renin, aldosterone and norepinephrine).

Timeline

Start
2016-07
Primary completion
2017-07
Completion
2017-08

Drugs

EvaluationDrugModalityDoseRoute
Subject Albumin Protein / enzyme biologic 80 g Intravenous
Subject Midodrine Small molecule 10 mg Oral
Subject Octreotide Peptide 0.2 mg Subcutaneous