Drugs / Midodrine
Midodrine
also known as
Midodrine hydrochloride · Midodrine HCl · ProAmatine · A-4020 LINZ · Amatine · Bramox · Gutron · Hipertan · +12 more
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | PROAMATINE | — | 1996-09-06 | fda.gov ↗ |
Trials 59 · a red edge is where a trial was stopped
Also used as a comparator or background therapy in 27 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 01 trial | ||||||
| Phase 0 | NCT04620382 Comparator | Nov 2020 → Jul 2025 | Parkinson disease, orthostatic hypotension, pure autonomic failure | Vanderbilt University Medical Center | Completed | No outcome recorded |
| Phase 11 trial | ||||||
| Phase 1 | NCT03129542 Comparator | Aug 2017 → Apr 2020 | infectious disease with sepsis | Mayo Clinic | Completed | No outcome recorded |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT07432997 Comparator | Dec 2023 → Sep 2024 | Alzheimer disease | Applied Cognition | Completed | No outcome recorded |
| Phase 22 trials | ||||||
| Phase 2 | NCT05778838 Comparator | Nov 2022 → Dec 2023 | infectious disease with sepsis | Noha Mansour | Completed | No outcome recorded |
| Phase 2 | NCT04048707 Comparator | Jul 2021 → Jun 2023 | acute kidney injury, cirrhosis of liver, hepatorenal syndrome | University of California, Los Angeles | Withdrawn | No outcome recorded |
| Phase 33 trials | ||||||
| Phase 3 | NCT04595942 Comparator | Nov 2020 → Oct 2023 | syncope, familial vasovagal | Tehran Heart Center | Unknown | No outcome recorded |
| Phase 3 | NCT04621617 Comparator | Nov 2020 → Dec 2021 | — | Post Graduate Institute of Medical Education and Research, Chandigarh | Unknown | No outcome recorded |
| Phase 3 | NCT01531959 Comparator | Apr 2012 → Jun 2019 | hypotensive disorder | Massachusetts General Hospital | Completed | No outcome recorded |
| Phase 48 trials | ||||||
| Phase 4 | NCT04440085 Comparator | Sep 2020 | orthostatic hypotension | Bürgerspital Solothurn | Unknown | No outcome recorded |
| Phase 4 | NCT03455322 Comparator | Aug 2018 → Apr 2020 | hepatorenal syndrome | National Hepatology & Tropical Medicine Research Institute | Completed | No outcome recorded |
| Phase 4 | NCT03350659 Comparator | Jan 2018 → Jan 2019 | orthostatic hypotension | Seoul National University Hospital | Completed | No outcome recorded |
| Phase 4 | NCT03911817 Comparator | Nov 2017 → Jun 2019 | infectious disease with sepsis | Ain Shams University | Completed | No outcome recorded |
| Phase 4 | NCT04668859 Comparator | Jul 2016 → Aug 2018 | isoproterenol-mediated vasodilatation | Medstar Health Research Institute | Terminated | No outcome recorded |
| Phase 4 | NCT01518946 Comparator | May 2012 → Jun 2013 | orthostatic hypotension | Shire | Completed | No outcome recorded |
| Phase 4 | NCT01456481 Comparator | Nov 2011 → Dec 2018 | syncope, familial vasovagal | Dr. Bob Sheldon | Unknown | No outcome recorded |
| Phase 4 | NCT00839358 Comparator | Aug 2008 → Feb 2016 | hepatic encephalopathy, infectious disease with sepsis, kidney failure | Hospital Clinic of Barcelona | Completed | No outcome recorded |
| Phase not applicable11 trials | ||||||
| — | NCT06930235 Comparator | Mar → Oct 2025 | — | Sohag University | Completed | No outcome recorded |
| — | NCT06213935 Comparator | Feb → Oct 2024 | — | Sohag University | Unknown | No outcome recorded |
| — | NCT06091345 Background | Dec 2023 → Dec 2025 | cirrhosis of liver | Institute of Liver and Biliary Sciences, India | Completed | No outcome recorded |
| — | NCT05803148 Comparator | Apr 2023 → Dec 2024 | syncope, familial vasovagal | China National Center for Cardiovascular Diseases | Unknown | No outcome recorded |
| — | NCT05548985 Comparator | Oct 2022 → Jul 2023 | hypotensive disorder | Cairo University | Completed | No outcome recorded |
| — | NCT04782830 Comparator | Feb 2021 → Jun 2027 expected | orthostatic hypotension, pure autonomic failure | Vanderbilt University Medical Center | Recruiting | No outcome recorded |
| — | NCT04396548 Comparator | Jun → Dec 2020 | — | Mansoura University | Completed | No outcome recorded |
| — | NCT03144713 Comparator | May 2017 → Apr 2018 | cirrhosis of liver | Institute of Liver and Biliary Sciences, India | Completed | No outcome recorded |
| — | NCT03431194 Comparator | Oct 2016 → Feb 2017 | acute kidney injury | Benha University | Completed | No outcome recorded |
| — | NCT02123576 Background | Apr 2014 → Dec 2017 | hepatorenal syndrome | Patrick Northup, MD | Terminated | No outcome recorded |
| — | NCT02365012 Comparator | Apr 2014 → Jun 2017 | Parkinson disease | Corporal Michael J. Crescenz VA Medical Center | Unknown | No outcome recorded |
Evidence & citations 24 cited values
Every value below carries the sentence it was read from. 89 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Midodrine | “These medications include beta-blockers, midodrine, ivabradine and stimulants.” NCT04881318 ↗80“Albumin, midodrine and octreotide therapy (standard of care for HRS)” NCT02123576 ↗ “Midodrine 2.5 mg orally 3 times daily, 5 day-treatment.” NCT01546506 ↗ |
| Known as | A-4020 LINZ | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201212 ↗ |
| Known as | Amatine | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201212 ↗ |
| Known as | Bramox | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201212 ↗ |
| Known as | Gutron | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201212 ↗ |
| Known as | Hipertan | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201212 ↗ |
| Known as | Metligine | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201212 ↗ |
| Known as | Midodrina | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201212 ↗ |
| Known as | Midodrine HCl | “Midodrine HCl Tablets 5 mg” NCT00650013 ↗ |
| Known as | Midodrine hydrochloride | “The purpose of this clinical study is to evaluate the clinical effect of midodrine hydrochloride (ProAmatine®) compared to placebo in patients with orthostatic hypotension by...” NCT00555880 ↗11“OBJECTIVE: To compare responses to head-up tilt (HUT) in individuals with chronic tetraplegia after midodrine hydrochloride (10 mg) versus nitro-L-arginine methyl ester...” PMID 21762873 ↗ Jul 2011 “The purpose of this clinical study is to further assess the clinical effect of high dose midodrine hydrochloride (ProAmatine®), an approved treatment for orthostatic hypotension.” NCT00046163 ↗ “Midodrine hydrochloride is a short-acting pressor agent that raises blood pressure in the upright position in patients with orthostatic hypotension.” PMID 27372462 ↗ Jul 2016 “Midodrine hydrochloride is an approved medication used to treat low blood pressure.” NCT01822535 ↗ “anti-hypotensive agent Midodrine Hydrochloride (midodrine).” NCT02307565 ↗ “Midodrine hydrochloride plus standard medical treatment” NCT05084534 ↗ “Drug: Midodrine Hydrochloride” NCT05240391 ↗ |
| Known as | Midodrine monohydrochloride | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201212 ↗ |
| Known as | Midodrine only | “Midodrine only” NCT03350659 ↗ |
| Known as | Midon | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201212 ↗ |
| Known as | NSC-758429 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201212 ↗ |
| Known as | Orvaten | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201212 ↗ |
| Known as | ProAmatine | “The purpose of this clinical study is to further assess the clinical effect of high dose midodrine hydrochloride (ProAmatine®), an approved treatment for orthostatic hypotension.” NCT00046163 ↗2“The purpose of this clinical study is to further assess the clinical benefit of midodrine hydrochloride (ProAmatine®), an approved treatment for orthostatic hypotension.” NCT00046475 ↗ “ProAmatine® Tablets 5 mg” NCT00648440 ↗ |
| Known as | ST 1085 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201212 ↗ |
| Known as | ST 1085 [AS THE BASE] | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201212 ↗ |
| Known as | ST 1085 HYDROCHLORIDE | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201212 ↗ |
| Known as | ST-1085 BASE | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201212 ↗ |
| Known as | ST-PETER-224 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201212 ↗ |
| Action | Activate | “alpha-receptor agonist midodrine” NCT00004268 ↗ |
| Modality | Small molecule | — CHEMBL1201212 ↗ |
| Route | Oral | “Patients receive oral midodrine three times a day” NCT00004268 ↗ |