drugset / Trial / NCT04881318
Compression Garments in the Community With POTS
RandomizedCrossoverOpen-labelTreatment
Summary
Compression Garments are a commonly prescribed treatment in Postural Orthostatic Tachycardia Syndrome (POTS). The effectiveness of a proof-of-concept compression garment has been demonstrated in an acute laboratory setting. It is not known if commercially available compression garments that participants wear in their every day lives are effective at improving heart rate and reducing symptoms in POTS. This trial will evaluate the use of commercially available waist-high and abdominal compression garments in adults diagnosed with POTS in a community setting.
Timeline
- Start
- 2021-05-17
- Primary completion
- 2026-12-31
- Completion
- 2026-12-31
Publications
- Bourne KM, Karalasingham K, Siddiqui T, Mammarella B, Patel A, Exner DV, Sheldon RS, Raj SR. Abdominal-only Compression Garments Reduce Orthostatic Tachycardia and Improve Symptoms in Patients With Postural Orthostatic Tachycardia Syndrome. Can J Cardiol. 2026 Jun;42(6):1320-1328. doi: 10.1016/j.cjca.2025.11.038. Epub 2025 Dec 1.
- Bourne KM, Karalasingham K, Siddiqui T, Patel A, Exner D, Sheldon R, Raj SR. A Community-Based Trial of Commercially Available Compression Tights in Patients With Postural Orthostatic Tachycardia Syndrome. JACC Clin Electrophysiol. 2025 Jan;11(1):179-190. doi: 10.1016/j.jacep.2024.09.033. Epub 2024 Nov 27.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Ivabradine | Small molecule | — | — |
| Subject | Midodrine | Small molecule | — | — |