The Effects of Potassium Nitrate in Reducing Dentinal Hypersensitivity
Summary
A randomized, controlled, double blind exploratory study to explore the effects of two different potassium nitrate concentrations and water on exposed dentine in reducing dentinal hypersensitivity. Solutions will be applied for either 2, 5 or 10 minutes and assessed by visual analogue scale (VAS) scores following evaporative (air) stimulus.
Timeline
- Start
- 2009-02
- Primary completion
- 2009-04
- Completion
- 2009-04
Outcome
Missed primary endpoint
registry analysis (superiority or other test); 5% KNO3 Solution (2 Minutes) vs Sterile Water (2 Minutes); p = 0.5718; Adjusted Mean Difference -3.89 (95% CI -17.59 to 9.80); ANCOVA NCT01587950 ↗
registry analysis (superiority or other test); 5% KNO3 Solution (10 Minutes) vs Sterile Water (10 Minutes); p = 0.4255; Adjusted Mean Difference -5.56 (95% CI -19.42 to 8.29); ANCOVA NCT01587950 ↗
registry analysis (superiority or other test); 5% KNO3 Solution (10 Minutes) vs Sterile Water (10 Minutes); p = 0.8703; Adjusted Mean Difference -1.07 (95% CI -14.11 to 11.97); ANCOVA NCT01587950 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Potassium Nitrate | Other / unclassified | 2.5 % | — |
| Subject | Potassium Nitrate | Other / unclassified | 5 % | — |