Drugs / Potassium Nitrate
Potassium Nitrate
also known as
KNO3 · E-252 · Emofrom Actisens · INS NO.252 · INS-252 · Kali nitricum · Nitre · NSC-57632 · +3 more
Trials 19 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 12 trials | ||||||
| Phase 1 | NCT03434782 | Apr → Nov 2017 | dentin sensitivity | Federal University of Pará | Completed | No outcome recorded |
| Phase 1 | NCT01587950 | Feb → Apr 2009 | dental pulp disorder, dentin sensitivity | GlaxoSmithKline | Completed | No outcome recorded |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT02797184 | Oct 2017 → Oct 2021 | heart failure | Washington University School of Medicine | Completed | No outcome recorded |
| Phase 28 trials | ||||||
| Phase 2 | NCT05562167 | Mar 2023 → May 2027 expected | heart failure | Washington University School of Medicine | Recruiting | No outcome recorded |
| Phase 2 | NCT03361774 | Oct → Dec 2018 | dentin sensitivity | GlaxoSmithKline | Withdrawn | No outcome recorded |
| Phase 2 | NCT03483051 | May 2018 → Mar 2019 | aortic valve stenosis | University of Pennsylvania | Completed | No outcome recorded |
| Phase 2 | NCT02840799 | Aug 2016 → Aug 2022 | heart failure | University of Pennsylvania | Completed | No outcome recorded |
| Phase 2 | NCT02918617 | May 2015 → Sep 2016 | dentin sensitivity | The University of Texas Health Science Center at San Antonio | Completed | No outcome recorded |
| Phase 2 | NCT02226562 | Sep → Dec 2014 | dentin sensitivity | GlaxoSmithKline | Completed | No outcome recorded |
| Phase 2 | NCT01115452 | Sep → Oct 2009 | dentin sensitivity | GlaxoSmithKline | Completed | No outcome recorded |
| Phase 2 | NCT00752089 | Sep 2007 → Jan 2008 | tooth erosion, non-bacterial | GlaxoSmithKline | Completed | No outcome recorded |
| Phase 31 trial | ||||||
| Phase 3 | NCT06956599 | May → Aug 2025 | dentin sensitivity | Colgate Palmolive | Completed | No outcome recorded |
| Phase not applicable7 trials | ||||||
| — | NCT07056855 | Jul 2025 overdue | dentin sensitivity | Cairo University | Not yet recruiting | No outcome recorded |
| — | NCT06896565 | Jun → Aug 2025 overdue | — | Cairo University | Not yet recruiting | No outcome recorded |
| — | NCT06871709 | May 2025 → Jan 2026 overdue | dental pulp disorder | Cairo University | Not yet recruiting | No outcome recorded |
| — | NCT06949072 | Apr → Sep 2025 | dental caries | HALEON | Completed | No outcome recorded |
| — | NCT07419763 | Apr → Jun 2025 | dental caries | Church & Dwight Company, Inc. | Completed | No outcome recorded |
| — | NCT05459558 | Sep → Dec 2022 | — | HALEON | Completed | No outcome recorded |
| — | NCT03166748 | Jun 2017 → Jul 2018 | tooth disorder | Cairo University | Unknown | No outcome recorded |
Also used as a comparator or background therapy in 20 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial | ||||||
| Phase 1 | NCT07027566 Comparator | Jul 2025 → May 2026 overdue | dentin sensitivity | Federal University of Pará | Not yet recruiting | No outcome recorded |
| Phase 25 trials | ||||||
| Phase 2 | NCT05138575 Comparator | Jan 2022 → May 2027 expected | diastolic heart failure | University of Pennsylvania | Recruiting | No outcome recorded |
| Phase 2 | NCT04913805 Comparator | Oct 2021 → May 2027 expected | diastolic heart failure | University of Pennsylvania | Recruiting | No outcome recorded |
| Phase 2 | NCT03627130 Comparator | Nov 2018 → May 2022 | acute coronary syndrome, acute kidney injury | Barts & The London NHS Trust | Completed | No outcome recorded |
| Phase 2 | NCT03323372 Comparator | Dec 2016 → May 2017 | dentin sensitivity | Federal University of Amazonas | Completed | No outcome recorded |
| Phase 2 | NCT02256345 Comparator | Jan 2015 → Jun 2016 | diastolic heart failure | University of Pennsylvania | Completed | No outcome recorded |
| Phase 35 trials | ||||||
| Phase 3 | NCT07215767 Comparator | Sep 2025 → Aug 2026 overdue | dentin sensitivity | HALEON | Active not recruiting | No outcome recorded |
| Phase 3 | NCT07478640 Comparator | Apr 2024 → Jun 2025 | dentin sensitivity | Federal University of Pará | Completed | No outcome recorded |
| Phase 3 | NCT06180707 Comparator | Jan → Mar 2024 | dentin sensitivity | Federal University of Pará | Unknown | No outcome recorded |
| Phase 3 | NCT03296072 Background | Nov 2017 → Jan 2018 | tooth erosion, non-bacterial | GlaxoSmithKline | Completed | No outcome recorded |
| Phase 3 | NCT02829879 Comparator | Dec 2015 → Sep 2016 | dentin sensitivity | University of Chile | Unknown | No outcome recorded |
| Phase 41 trial | ||||||
| Phase 4 | NCT06608368 Comparator | Oct → Nov 2024 | dentin sensitivity | HALEON | Completed | No outcome recorded |
| Phase not applicable8 trials | ||||||
| — | NCT06967818 Background | Jul → Dec 2025 | dentin sensitivity | University of Pavia | Completed | No outcome recorded |
| — | NCT06746558 Comparator | Jan → Oct 2023 | dentin sensitivity | University of Modena and Reggio Emilia | Completed | No outcome recorded |
| — | NCT03965039 Comparator | Jul → Oct 2019 | dentin sensitivity | Procter and Gamble | Completed | No outcome recorded |
| — | NCT02613130 Comparator | Nov → Dec 2015 | mouth disorder | Procter and Gamble | Completed | No outcome recorded |
| — | NCT02956070 Comparator | Oct 2015 → May 2016 | — | Fluminense Federal University | Completed | No outcome recorded |
| — | NCT02931734 Comparator | Oct 2014 → Jan 2015 | dentin sensitivity | Federal University of Uberlandia | Completed | No outcome recorded |
| — | NCT01657903 Background | Nov 2011 → Feb 2012 | tooth erosion, non-bacterial | GlaxoSmithKline | Completed | No outcome recorded |
| — | NCT01345292 Comparator | Apr → May 2011 | dentin sensitivity | Johnson & Johnson Consumer and Personal Products Worldwide | Completed | No outcome recorded |
Evidence & citations 14 cited values
Every value below carries the sentence it was read from. 42 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | potassium nitrate | “Dentifrice containing 5 percent (%) weight by weight (w/w) Potassium nitrate (KNO3) and 1150ppm fluoride as sodium fluoride.” NCT06949072 ↗34“5 percent (%) potassium nitrate (KNO3) dentifrice with 1% alumina and 5% sodium tripolyphosphate (STP).” NCT05459558 ↗ “Test dentifrice containing 0.243% sodium fluoride, 5.0% potassium nitrate, and 20% sodium bicarbonate.” NCT07419763 ↗ “5% Potassium Nitrate Toothpaste” NCT06956599 ↗ “5% KNO3 \[potassium nitrate\]” NCT03296072 ↗ “5% potassium nitrate (KNO3)” NCT00752089 ↗ |
| Known as | E-252 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1644029 ↗ |
| Known as | Emofrom Actisens | “Topical application of a 5% potassium nitrate gel (Emofrom Actisens) used to treat dentin hypersensitivity.” NCT06967818 ↗ |
| Known as | INS NO.252 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1644029 ↗ |
| Known as | INS-252 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1644029 ↗ |
| Known as | Kali nitricum | ChEMBL registry synonym — accepted as the source's own label CHEMBL1644029 ↗ |
| Known as | KNO3 | “An exploratory study investigating the direct application of potassium nitrate (KNO3) solutions of different concentrations in reducing dentine hypersensitivity.” NCT01115452 ↗17“marketed potassium nitrate (KNO3), marketed stannous fluoride (SnF2), experimental 1.5% oxalate, or negative control (NC) monofluorophosphate.” PMID 40444818 ↗ May 2025 “Potassium Nitrate (KNO3) capsules, providing 6 millimoles of inorganic nitrate per capsule, to be taken three times daily for 6 weeks.” NCT02840799 ↗ “Dentifrice containing 5 percent (%) weight by weight (w/w) Potassium nitrate (KNO3) and 1150ppm fluoride as sodium fluoride.” NCT06949072 ↗ “5 percent (%) potassium nitrate (KNO3) dentifrice with 1% alumina and 5% sodium tripolyphosphate (STP).” NCT05459558 ↗ “Potassium Nitrate (KNO3) is an effective desensitizer for hypersensitive teeth9.” NCT06871709 ↗ “Dentifrice containing 5% w/w KNO3 and 1150 ppm fluoride as sodium fluoride.” NCT06608368 ↗ “novel stannous fluoride (SnF2) and potassium nitrate (KNO3) dentifrice” NCT07215767 ↗ “3% potassium nitrate (KNO3) mouthrinse plus fluoride toothpaste” PMID 30803493 ↗ Mar 2019 “Test toothpaste with nano-HAP and (Potassium Nitrate) KNO3” NCT02918617 ↗ “potassiun nitrate (KNO3),Merck,darmstadt,germany” NCT03166748 ↗ “Potassium Nitrate (KNO3)” NCT03483051 ↗ “KNO3, potassium nitrate” NCT02797184 ↗ |
| Known as | Nitre | ChEMBL registry synonym — accepted as the source's own label CHEMBL1644029 ↗ |
| Known as | NSC-57632 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1644029 ↗ |
| Known as | potassiun nitrate | “potassiun nitrate (KNO3),Merck,darmstadt,germany” NCT03166748 ↗ |
| Known as | Saltpeter | ChEMBL registry synonym — accepted as the source's own label CHEMBL1644029 ↗ |
| Known as | Saltpetre | ChEMBL registry synonym — accepted as the source's own label CHEMBL1644029 ↗ |
| Modality | Other / unclassified | “inorganic nitrate” NCT03483051 ↗ |
| Route | Topical | “Participants to brush their teeth for one timed minute twice daily with a gel to foam dentifrice, containing as active ingredients: 1450 ppm NaF and 5% KNO3 but no isopentane.” NCT00752089 ↗ |