drugset
drugset / Trial / NCT03483051

Targeting Pulsatile Load to Increase Exercise Capacity and Quality of Life After Aortic Valve Replacement for Severe Aortic Stenosis (PULSE AS)

NCT03483051 ↗

Phase 2 Completed 5 enrolled University of Pennsylvania
RandomizedCrossoverQuadruple-blindTreatment

Summary

The current trial is designed to assess the safety and efficacy of sustained oral administration of inorganic nitrate in patients with severe aortic stenosis and to assess the mechanisms by which inorganic nitrate enhances oxygen uptake and exercise capacity in this population.

Timeline

Start
2018-05-01
Primary completion
2019-03-13
Completion
2019-05-23

Drugs

EvaluationDrugModalityDoseRoute
Comparator Potassium Chloride Small molecule 6 mmol Oral
Subject Potassium Nitrate Other / unclassified 6 mmol Oral

Indications

aortic valve stenosis