drugset / Trial / NCT01596764
Effects of Methylnaltrexone in Comparison to Naloxone on Loperamide-induced Delay of the Oro-cecal, Whole-gut and Colon Transit Time.
RandomizedCrossoverTriple-blindBasic science
Summary
The purpose of this study is to describe the effects of repeated-dose methylnaltrexone in preventing loperamide-induced delay of whole-gut, oro-cecal and colon transit time and to measure pharmacokinetics of methylnaltrexone and naloxone-3-glucuronide after oral administration of methylnaltrexone and naloxone.
Timeline
- Start
- 2011-05
- Primary completion
- 2011-07
- Completion
- 2012-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Methylnaltrexone | Other / unclassified | 150 mg | Oral |
| Comparator | Naloxone | Small molecule | 20 mg | Oral |
| Comparator | Loperamide | Small molecule | 4 mg | — |
| Comparator | Sulfasalazine | Small molecule | 500 mg | — |