drugset / Trial / NCT01596777
Effects of 500 mg Immediate Release and Extended Release Methylnaltrexone on Loperamide-induced Delay of the Oro-cecal and Whole-gut Transit Time in Healthy Subjects
RandomizedCrossoverTriple-blindBasic science
Summary
The purpose of this study is to describe the effects of methylnaltrexone in preventing loperamide-induced delay of the oro-cecal and whole-gut transit time and measure pharmacokinetics of methylnaltrexone after subcutaneous and oral administration of immediate release and extended release capsules.
Timeline
- Start
- 2010-01
- Primary completion
- 2010-03
- Completion
- 2010-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Loperamide | Small molecule | — | — |
| Comparator | Methylnaltrexone | Other / unclassified | 12 mg | Subcutaneous |
| Comparator | Methylnaltrexone | Other / unclassified | 500 mg | Subcutaneous |
| Comparator | Sulfasalazine | Small molecule | 500 mg | — |