drugset / Trial / NCT01620177
Effects of Inhaled Cannabis on Driving Performance
Completed
98 enrolled
Gary R Gaffney
National Highway Traffic Safety Administration (NHTSA) · collabNational Institute on Drug Abuse (NIDA) · collab
RandomizedCrossoverTriple-blindBasic science
Summary
The purpose of this study is to expand understanding of the effects of cannabis on driving performance with and without the presence of low levels of alcohol. This project will involve the development a of a protocol and driving environment that is sensitive to the effects of cannabis on driving performance by building on prior driving situations used previously for testing the effects of alcohol on driving.
Timeline
- Start
- 2012-07
- Primary completion
- 2014-03
- Completion
- 2014-03
Publications
- Results Hartman RL, Brown TL, Milavetz G, Spurgin A, Pierce RS, Gorelick DA, Gaffney G, Huestis MA. Cannabis effects on driving lateral control with and without alcohol. Drug Alcohol Depend. 2015 Sep 1;154:25-37. doi: 10.1016/j.drugalcdep.2015.06.015. Epub 2015 Jun 23.
- Results Hartman RL, Brown TL, Milavetz G, Spurgin A, Gorelick DA, Gaffney G, Huestis MA. Controlled Cannabis Vaporizer Administration: Blood and Plasma Cannabinoids with and without Alcohol. Clin Chem. 2015 Jun;61(6):850-69. doi: 10.1373/clinchem.2015.238287. Epub 2015 May 27.
- Results Hartman RL, Brown TL, Milavetz G, Spurgin A, Gorelick DA, Gaffney G, Huestis MA. Controlled vaporized cannabis, with and without alcohol: subjective effects and oral fluid-blood cannabinoid relationships. Drug Test Anal. 2016 Jul;8(7):690-701. doi: 10.1002/dta.1839. Epub 2015 Aug 10.
- Results Hartman RL, Brown TL, Milavetz G, Spurgin A, Pierce RS, Gorelick DA, Gaffney G, Huestis MA. Cannabis effects on driving longitudinal control with and without alcohol. J Appl Toxicol. 2016 Nov;36(11):1418-29. doi: 10.1002/jat.3295. Epub 2016 Feb 18.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Alcohol | Other / unclassified | — | Oral |
| Subject | Cannabis | Traditional medicine (herbal / TCM) | 0 mg | Inhaled |
| Subject | Cannabis | Traditional medicine (herbal / TCM) | 12.5 mg | Inhaled |
| Subject | Cannabis | Traditional medicine (herbal / TCM) | 30 mg | Inhaled |