GnRH Agonist (GnRHa) Withdrawal at Late Stage of Long Protocol and the Incidence of Ovarian Hyper-stimulation

Unknown 96 enrolled Nanjing University

RandomizedParallel-groupTriple-blindPrevention

Summary

To test whether GnRHa withheld 2-3 days before ovulation trigger reduces the incidence of ovarian hyperstimulation syndrome (OHSS) in infertile high-risk patients with polycystic ovaries (PCOs) who have been treated with gonadotropins for in vitro fertilization (IVF) or Intracytoplasmic sperm injection (ICSI).

Timeline

Start: 2012-07
Primary completion: 2012-07
Completion: 2013-06

Publications

Background Ho Yuen B, Nguyen TA, Cheung AP, Leung PC. Clinical and endocrine response to the withdrawal of gonadotropin-releasing hormone agonists during prolonged coasting. Fertil Steril. 2009 Aug;92(2):499-507. doi: 10.1016/j.fertnstert.2008.06.039. Epub 2008 Aug 15.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Triptorelin	Other / unclassified	0.05 mg	—
Background	Gonal-f	Protein / enzyme biologic	150 iu	—
Background	Gonal-f	Protein / enzyme biologic	250 iu	—

Indications

No indication recorded.