drugset / Trial / NCT01635608

Absorption of Paracetamol, Talinolol and Amoxicillin After Oral Administration Using Non-caloric and Caloric Water

NCT01635608

Phase 1 Completed 12 enrolled University Medicine Greifswald
RandomizedCrossoverOpen-labelBasic science

Summary

To visualize the localization and to measure the volume of water in the small intestine by T2-weighted MRI imaging after oral administration of 240 ml water (non-caloric water) and after administration of 240 ml water containing 25.5 g sucrose (105 kcal, caloric water). To measure pharmacokinetics of the probe-drugs paracetamol, talinolol and amoxicillin after oral administration dissolved in 240 ml non-caloric and in 240 ml caloric water.

Timeline

Start
2011-04
Primary completion
2011-07
Completion

Drugs

EvaluationDrugModalityDoseRoute
Comparator Acetaminophen Small molecule 500 mg Oral
Comparator Amoxicillin Other / unclassified 500 mg Oral
Comparator Talinolol Small molecule 50 mg Oral

Indications

No indication recorded.