Study of Cardiovascular Disease and Obstructive Sleep Apnea

Phase 2 Completed 87 enrolled University of Wisconsin, Madison National Heart, Lung, and Blood Institute (NHLBI) · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this study is to determine if two medicines (allopurinol and losartan) can influence heart and blood vessel health compared to placebo in patients with sleep apnea who are using continuous positive airway pressure (CPAP).

Timeline

Start: 2012-06
Primary completion: 2015-06
Completion: 2015-06

Publications

Results Morgan BJ, Teodorescu M, Pegelow DF, Jackson ER, Schneider DL, Plante DT, Gapinski JP, Hetzel SJ, Dopp JM. Effects of losartan and allopurinol on cardiorespiratory regulation in obstructive sleep apnoea. Exp Physiol. 2018 Jul;103(7):941-955. doi: 10.1113/EP087006. Epub 2018 Jun 8.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Allopurinol	Small molecule	300 mg	—
Comparator	Losartan	Other / unclassified	50 mg	—

Study of Cardiovascular Disease and Obstructive Sleep Apnea

Summary

Timeline

Publications

Drugs

Indications