drugset / Trial / NCT01643070
Preoperative CRT With or Without Induction Chemotherapy for Rectal Cancer With Liver Metastases
RandomizedFactorialOpen-labelTreatment
Summary
To investigate the feasibility of preoperative chemoradiation with oxaliplatin plus capecitabine, with or without prior induction chemotherapy in patients with locally advanced or marginally resectable rectal cancer with resectable synchronous liver metastases.
Timeline
- Start
- 2010-01
- Primary completion
- 2014-09
- Completion
- 2015-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Capecitabine | Small molecule | 825 mg/m2 | Oral |
| Comparator | Capecitabine | Small molecule | 1250 mg/m2 | Oral |
| Comparator | Oxaliplatin | Small molecule | 50 mg/m2 | — |
| Comparator | Oxaliplatin | Small molecule | 130 mg/m2 | — |