Incobotulinum Toxin A (Xeomin®) for Troublesome Sialorrhea in Parkinson's Disease (PD)/Parkinsonism

Summary

This study is being conducted this study to determine whether injections of Xeomin®, a type of botulinum toxin into the glands that produce saliva (one pair just below and in front of the ear and the other just under the jaw line) are safe and effective to treat excessive saliva, or drooling in patients with Parkinson's Disease (PD)/parkinsonism.

Timeline

Start

2012-03

Primary completion

2014-09

Completion

2014-09

Outcome

Missed primary endpoint

registry Mean Difference (Net) -0.194 (95% CI -0.71 to 0.32) NCT01653132 ↗

registry Mean Difference (Net) -22.3 (95% CI -50.8 to 6.2) NCT01653132 ↗

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Botulinum toxin type A	Protein / enzyme biologic	100 iu	Other

Indications

No indication recorded.