Pioglitazone in Thyroid Cancers

Phase 2 Completed 1 enrolled University of Michigan National Cancer Institute (NCI) · collab

NaSingle-groupOpen-labelTreatment

Summary

Through this trial the investigators hope to learn if a drug, Actos (pioglitazone), is useful in treating a certain kind of metastatic thyroid cancer. Actos is approved by the FDA to treat diabetes. It has not been approved by the FDA to treat cancer, so its use in this study is considered experimental.

Timeline

Start: 2012-04
Primary completion: 2017-03-31
Completion: 2017-03-31

Publications

Giordano TJ, Haugen BR, Sherman SI, Shah MH, Caoili EM, Koenig RJ. Pioglitazone Therapy of PAX8-PPARgamma Fusion Protein Thyroid Carcinoma. J Clin Endocrinol Metab. 2018 Apr 1;103(4):1277-1281. doi: 10.1210/jc.2017-02533.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Pioglitazone	Small molecule	—	—

Indications

No indication recorded.