drugset / Trial / NCT01659307
The Effect of Aspirin on REducing iNflammation in Human in Vivo Model of Acute Lung Injury
Phase 2
Completed
33 enrolled
Belfast Health and Social Care Trust
Northern Ireland Clinical Trials Unit · collabQueen's University, Belfast · collabThe Intensive Care Society United Kingdom · collab
RandomizedParallel-groupQuadruple-blindPrevention
Summary
This is a double-blind, placebo-controled, randomized trial to investigate if aspirin pre-treatment has anti-inflammatory effects in a model of acute lung injury induced by inhaled endotoxin (LPS) in healthy human volunteers.
Timeline
- Start
- 2012-09
- Primary completion
- 2022-09-09
- Completion
- 2022-09-09
Publications
- Hamid U, Krasnodembskaya A, Fitzgerald M, Shyamsundar M, Kissenpfennig A, Scott C, Lefrancais E, Looney MR, Verghis R, Scott J, Simpson AJ, McNamee J, McAuley DF, O'Kane CM. Aspirin reduces lipopolysaccharide-induced pulmonary inflammation in human models of ARDS. Thorax. 2017 Nov;72(11):971-980. doi: 10.1136/thoraxjnl-2016-208571. Epub 2017 Jan 12.
- Toner P, McAuley DF, Shyamsundar M. Aspirin as a potential treatment in sepsis or acute respiratory distress syndrome. Crit Care. 2015 Oct 23;19:374. doi: 10.1186/s13054-015-1091-6.
- Curley GF, McAuley DF. Stem cells for respiratory failure. Curr Opin Crit Care. 2015 Feb;21(1):42-9. doi: 10.1097/MCC.0000000000000171.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Aspirin | Small molecule | 75 mg | Oral |
| Comparator | Aspirin | Small molecule | 600 mg | Oral |