drugset / Trial / NCT01661595
The Effect of Sildenafil and Tadalafil on Skeletal Muscle and Perceptual Fatigue
RandomizedCrossoverTriple-blindTreatment
Summary
This study is funded by the Moody Endowment. In this project, we will investigate the potential effect of skeletal muscle nitric oxide (NO) production on skeletal muscle anabolism, muscle strength, physical function, and body composition in older individuals. Further, we will determine whether augmentation of NO-mediated signaling reduces fatigue and fatigability.
Timeline
- Start
- 2012-11
- Primary completion
- 2015-06
- Completion
- 2015-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Sildenafil | Unknown | 50 mg | — |
| Comparator | Tadalafil | Small molecule | 10 mg | — |
Indications
No indication recorded.