drugset / Trial / NCT01681264
Effect of Guanfacine on Opioid-induced Hyperalgesia (OIH) and Tolerance
Phase 4
Terminated
137 enrolled
Massachusetts General Hospital
National Institute on Drug Abuse (NIDA) · collabNational Institutes of Health (NIH) · collab
RandomizedSingle-groupTriple-blindTreatment
Summary
Dual medication (guanfacine and morphine) as a standard treatment for chronic pain.
Timeline
- Start
- 2014-09
- Primary completion
- 2022-12
- Completion
- 2023-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Guanfacine | Small molecule | 1 mg | — |
| Comparator | Guanfacine | Small molecule | 2 mg | — |
| Comparator | Morphine | Other / unclassified | — | — |