Cardioprotective and Metabolic Effects of Metformin in Patients With Heart Failure and Diabetes

Summary

The aim of the study is to evaluate the effect of metformin on myocardial function, insulin resistance and selected metabolic markers in patients with type 2 diabetes and heart failure (HF+DM+) in a cross-over, randomized, placebo controlled trial. Hypothesis: Metformin treatment in HF+DM+ group will lead to better myocardial function and load tolerance in comparison to placebo. The degree of improvement will be linked to selected metabolic parameters.

Timeline

Start

2012-11

Primary completion

2016-05

Completion

2016-12

Drugs

Indications