drugset / Trial / NCT01690338
A Study of Residual Curarization Incidence in China
Phase 4
Unknown
6090 enrolled
Peking University First Hospital
Central South University · collabChina Medical University Hospital · collabChinese PLA General Hospital · collabEastern Hepatobiliary Surgery Hospital · collabFirst Affiliated Hospital of Xinjiang Medical University · collabFirst Affiliated Hospital of Zhejiang University · collabFirst Affiliated Hospital, Sun Yat-Sen University · collabHebei Medical University Fourth Hospital · collabPeking Union Medical College Hospital · collabRenJi Hospital · collabRuijin Hospital · collabShanghai General Hospital, Shanghai Jiao Tong University School of Medicine · collabShanghai Zhongshan Hospital · collabThe First Affiliated Hospital of Guangzhou Medical University · collabThe First Affiliated Hospital of Zhengzhou University · collabTianjin Medical University General Hospital · collabTongji Hospital · collabUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology · collabWest China Hospital · collabXiangya Hospital of Central South University · collabZhujiang Hospital · collab
RandomizedParallel-groupDouble-blindTreatment
Summary
The purpose of this study is to determine the incidence of residual curarization in PACU and relevant risk factors.
Timeline
- Start
- 2012-10
- Primary completion
- 2014-10
- Completion
- 2014-12
Publications
- Background Cammu G, De Witte J, De Veylder J, Byttebier G, Vandeput D, Foubert L, Vandenbroucke G, Deloof T. Postoperative residual paralysis in outpatients versus inpatients. Anesth Analg. 2006 Feb;102(2):426-9. doi: 10.1213/01.ane.0000195543.61123.1f.
- Background Naguib M, Kopman AF, Lien CA, Hunter JM, Lopez A, Brull SJ. A survey of current management of neuromuscular block in the United States and Europe. Anesth Analg. 2010 Jul;111(1):110-9. doi: 10.1213/ANE.0b013e3181c07428. Epub 2009 Nov 12.
- Background Naguib M, Kopman AF, Ensor JE. Neuromuscular monitoring and postoperative residual curarisation: a meta-analysis. Br J Anaesth. 2007 Mar;98(3):302-16. doi: 10.1093/bja/ael386.
- Background Hayes AH, Mirakhur RK, Breslin DS, Reid JE, McCourt KC. Postoperative residual block after intermediate-acting neuromuscular blocking drugs. Anaesthesia. 2001 Apr;56(4):312-8. doi: 10.1046/j.1365-2044.2001.01921.x.
- Background Baillard C, Clec'h C, Catineau J, Salhi F, Gehan G, Cupa M, Samama CM. Postoperative residual neuromuscular block: a survey of management. Br J Anaesth. 2005 Nov;95(5):622-6. doi: 10.1093/bja/aei240. Epub 2005 Sep 23.
- Background Cammu G, de Baerdemaeker L, den Blauwen N, de Mey JC, Struys M, Mortier E. Postoperative residual curarization with cisatracurium and rocuronium infusions. Eur J Anaesthesiol. 2002 Feb;19(2):129-34. doi: 10.1017/s0265021502000236.
- Background Baillard C, Gehan G, Reboul-Marty J, Larmignat P, Samama CM, Cupa M. Residual curarization in the recovery room after vecuronium. Br J Anaesth. 2000 Mar;84(3):394-5. doi: 10.1093/oxfordjournals.bja.a013445.
- Background Murphy GS, Szokol JW, Marymont JH, Franklin M, Avram MJ, Vender JS. Residual paralysis at the time of tracheal extubation. Anesth Analg. 2005 Jun;100(6):1840-1845. doi: 10.1213/01.ANE.0000151159.55655.CB.
- Background Debaene B, Plaud B, Dilly MP, Donati F. Residual paralysis in the PACU after a single intubating dose of nondepolarizing muscle relaxant with an intermediate duration of action. Anesthesiology. 2003 May;98(5):1042-8. doi: 10.1097/00000542-200305000-00004.
- Background Srivastava A, Hunter JM. Reversal of neuromuscular block. Br J Anaesth. 2009 Jul;103(1):115-29. doi: 10.1093/bja/aep093. Epub 2009 May 24.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Cisatracurium | Small molecule | — | — |
| Comparator | Rocuronium | Other / unclassified | — | — |
| Comparator | Vecuronium | Small molecule | — | — |