drugset / Trial / NCT01690403
Interaction Study to Assess the Pharmacokinetic Interaction of Oral Administration of Rifapentine on ATRIPLA™ in HIV Patients
Non-randomizedParallel-groupOpen-labelBasic science
Summary
Primary Objective: \- To evaluate the effect of single and repeated administration of rifapentine given as daily or weekly regimen on steady-state pharmacokinetic parameters of efavirenz, emtricitabine and tenofovir given as a fixed dose combination (ATRIPLA™ ). Secondary Objective: \- To evaluate the safety and tolerability of concomitant administration of rifapentine and ATRIPLA™ given to HIV+ patients
Timeline
- Start
- 2012-12
- Primary completion
- 2014-03
- Completion
- 2014-03
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Efavirenz | Other / unclassified | — | Oral |
| Subject | Rifapentine | Small molecule | — | Oral |
| Subject | Tenofovir disoproxil fumarate | Small molecule | — | Oral |
| Subject | emtricitabine | Other / unclassified | — | Oral |