Clinical Trial With Clobetasol and Dexamethasone for Topical Treatment of Oral Lesions of Chronic Graft-versus-host Disease

Phase 3 Completed 28 enrolled Grupo de Estudos Multicentricos em Onco-Hematologia

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this study is to perform a randomized, double-blind, clinical trial comparing the topical treatment with clobetasol or dexamethasone for symptomatic oral lesions of chronic graft-versus-host disease.

Timeline

Start: 2008-08
Primary completion: 2012-07
Completion: 2012-08

Publications

Background Noce CW, Gomes A, Copello A, Barbosa RD, Sant'anna S, Moreira MC, Correa ME, Maiolino A, Torres SR. Oral involvement of chronic graft-versus-host disease in hematopoietic stem cell transplant recipients. Gen Dent. 2011 Nov-Dec;59(6):458-62; quiz 463-4.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Clobetasol	Small molecule	0.05 %	Topical
Subject	Dexamethasone	Small molecule	0.1 mg/ml	Topical
Background	Nystatin	Unknown	100000 iu	Topical

Clinical Trial With Clobetasol and Dexamethasone for Topical Treatment of Oral Lesions of Chronic Graft-versus-host Disease

Summary

Timeline

Publications

Drugs

Indications