Exercise, Statins, and the Metabolic Syndrome

Summary

Here we tested if statins or exercise plus statins had a greater capacity to lower metabolic syndrome risk factors in sedentary individuals with at least 2 metabolic syndrome risk factors. We also examined if statins impacted exercise response for mitochondrial content in muscle or aerobic fitness.

Timeline

Start

2007-05

Primary completion

2011-05

Completion

2011-05

Outcome

Met primary endpoint

paper resulting in only a 1.5% increase (p < 0.005 for group by time interaction). PMID 23583255 ↗

Publications

• Mikus CR, Boyle LJ, Borengasser SJ, Oberlin DJ, Naples SP, Fletcher J, Meers GM, Ruebel M, Laughlin MH, Dellsperger KC, Fadel PJ, Thyfault JP. Simvastatin impairs exercise training adaptations. J Am Coll Cardiol. 2013 Aug 20;62(8):709-14. doi: 10.1016/j.jacc.2013.02.074. Epub 2013 Apr 10.

Drugs

Indications