Validation of a Lung Inflammation Model in Healthy Volunteers by Radiological Tools and Glucocorticoid Treatment

Summary

The purpose of this study is to investigate the local and systemic inflammatory response and haemostatic alterations in the lungs after lipopolysaccharide (LPS) instillation and to determine the feasibility of imaging techniques to quantify lung inflammation in an adapted human endotoxin instillation model. The investigators will also explore whether glucocorticoid treatment can blunt LPS effects.

Timeline

Start

2011-07

Primary completion

2012-06

Completion

2012-06

Drugs

Indications