Progestin-induced Endometrial Shedding in PCOS (The PIES in PCOS Study)
Summary
Progestin-induced endometrial shedding (PIES) followed by clomiphene citrate is fertility treatment of choice in anovulatory women with polycystic ovary syndrome (PCOS). However, some preliminary data suggest that skipping PIES could result in a higher live birth rate. The investigators are performing the first randomized controlled trial to find out if skipping the use of progestin during fertility treatment of anovulatory PCOS women is associated with improved pregnancy and live birth rates compared to the traditional approach of using progestin prior to use of clomiphene citrate.
Timeline
- Start
- 2015-03
- Primary completion
- 2016-06
- Completion
- 2016-06
Outcome
Outcome not reported
Stopped: “The primary investigator moved from academic practice to join a private group, and could not get any one to take over as PI for the study.”
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Clomiphene Citrate | Other / unclassified | 50 mg | Oral |
| Subject | Clomiphene Citrate | Other / unclassified | 100 mg | Oral |
| Subject | Clomiphene Citrate | Other / unclassified | 150 mg | Oral |
| Comparator | medroxyprogesterone acetate | Other / unclassified | 10 mg | Oral |