drugset / Trial / NCT01718587

Difference in Efficacy Between Stem Cell Transplantation and Classical Therapy in Liver Cirrhosis Patients

NCT01718587

RandomizedParallel-groupOpen-labelTreatment

Summary

The current treatment methods of liver cirrhosis are limited ,including antiviral therapy,supportive therapy and liver transplantation. Antiviral therapy and Supportive therapy especially the regularly intravenous infusions of plasma or albumin are combined in the clinical classical therapy treatment. In the other hand,umbilical cord mesenchyma stem cell with self and directed differentiation capacity can effectively rescue experimental liver failure and contribute to liver regeneration, which suggests the feasibility of stem cell transplantation therapy. In this study, the safety and efficacy of umbilical cord mesenchyma stem cell transplantation through interventional procedures and classical therapy in patients liver cirrhosis will be evaluated and compared.

Timeline

Start
2012-11
Primary completion
2013-05
Completion
2014-07

Drugs

EvaluationDrugModalityDoseRoute
Comparator Adefovir dipivoxil Small molecule 10 mg Oral
Comparator Entecavir Small molecule 0.5 mg Oral
Comparator Entecavir Small molecule 1 mg Oral
Comparator Lamivudine Other / unclassified 100 mg Oral
Comparator Telbivudine Small molecule 600 mg Oral

Indications