drugset / Trial / NCT01724268
Corticosteroids and Anti TNF in Methotrexate Inadequate Responder Rheumatoid Arthritis Patient
RandomizedParallel-groupOpen-labelTreatment
Summary
Compare the efficacy of adding small doses of prednisolone (10 mg) daily to the efficacy of adding one of the available anti TNF in the treatment of methotrexate inadequate responder rheumatoid arthritis patient. Hypothesis: Methotrexate + Prednisolone vs. Methotrexate + anti TNF
Timeline
- Start
- 2012-05
- Primary completion
- 2014-05
- Completion
- 2014-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Adalimumab | Monoclonal antibody | 40 mg | — |
| Comparator | Etanercept | Protein / enzyme biologic | 50 mg | — |
| Comparator | Infliximab | Monoclonal antibody | 3 mg/kg | — |
| Subject | Prednisolone | Other / unclassified | 10 mg | Oral |
| Background | Methotrexate | Small molecule | 25 mg | — |