Safety Study of a Dual Anti-HIV Gene Transfer Construct to Treat HIV-1 Infection

Summary

This is an early phase research study looking at whether an experimental gene transfer, LVsh5/C46 (also known as Cal-1), is safe and if it can protect the immune system from the effects of HIV without the use of antiretroviral drugs. Cal-1 is an experimental gene transfer agent designed to inhibit HIV infection through 2 active parts: 1. Removing a protein named CCR5 from bone marrow and white blood cells 2. Producing a protein named C46 on bone marrow and white blood cells

Timeline

Start

2013-04

Primary completion

2017-09

Completion

2017-11

Drugs

Indications