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drugset / Trial / NCT01740817

A Study to Evaluate the Effect of Lipid Infusion on Toll Like Receptor 4 (TLR4) Signaling

NCT01740817 ↗

Completed 12 enrolled The University of Texas Health Science Center at San Antonio National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · collab

RandomizedCrossoverOpen-labelBasic science

Summary

The purpose of this study is to determine whether a lipid infusion can up-regulate toll-like receptor 4 (TLR4) signaling in human subjects

Timeline

Start: 2008-01
Primary completion: 2013-12
Completion: 2015-09

Publications

Hussey SE, Lum H, Alvarez A, Cipriani Y, Garduno-Garcia J, Anaya L, Dube J, Musi N. A sustained increase in plasma NEFA upregulates the Toll-like receptor network in human muscle. Diabetologia. 2014 Mar;57(3):582-91. doi: 10.1007/s00125-013-3111-x. Epub 2013 Dec 14.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Intralipid	Other / unclassified	30 ml	Other

Indications