Dexamethasone in Reducing Oral Pain and Dry Mouth After Surgery in Patients With Oropharyngeal Cancer

Completed 76 enrolled OHSU Knight Cancer Institute National Cancer Institute (NCI) · collab

RandomizedParallel-groupDouble-blindSupportive care

Summary

This randomized pilot clinical trial studies dexamethasone in reducing oral pain and dry mouth after surgery in patients with oropharyngeal cancer. Dexamethasone may help lower pain and dry mouth caused by surgery.

Timeline

Start: 2012-12
Primary completion: 2016-07
Completion: 2017-03-29

Outcome

Missed primary endpoint

registry analysis (superiority test); Arm I (Treatment) vs Arm II (Control); p = 0.25; Mixed Models Analysis NCT01748942 ↗

Publications

Clayburgh D, Stott W, Bolognone R, Palmer A, Achim V, Troob S, Li R, Brickman D, Graville D, Andersen P, Gross ND. A randomized controlled trial of corticosteroids for pain after transoral robotic surgery. Laryngoscope. 2017 Nov;127(11):2558-2564. doi: 10.1002/lary.26625. Epub 2017 Aug 29.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexamethasone	Small molecule	8 mg	Intravenous