Topiramate Treatment of Hazardous and Harmful Alcohol Use in Veterans With TBI

Phase 4 Completed 32 enrolled University of California, San Francisco Northern California Institute of Research and Education · collab San Francisco Veterans Affairs Medical Center · collab United States Department of Defense · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

The goal of the proposed project is to improve the treatment of veterans with co-occurring traumatic brain injury (TBI) and hazardous or harmful alcohol use. The PI and coinvestigators will conduct a pilot controlled clinical trial of topiramate for the treatment of these co-occurring disorders.

Timeline

Start: 2012-11
Primary completion: 2015-10
Completion: 2015-10

Publications

Results Pennington DL, Bielenberg J, Lasher B, Herbst E, Abrams G, Novakovic-Agopian T, Batki SL. A randomized pilot trial of topiramate for alcohol use disorder in veterans with traumatic brain injury: Effects on alcohol use, cognition, and post-concussive symptoms. Drug Alcohol Depend. 2020 Sep 1;214:108149. doi: 10.1016/j.drugalcdep.2020.108149. Epub 2020 Jul 2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Topiramate	Small molecule	300 mg	—

Topiramate Treatment of Hazardous and Harmful Alcohol Use in Veterans With TBI

Summary

Timeline

Publications

Drugs

Indications